June 18, 2014
Melatonin in autism spectrum disorders: a systematic review and meta-analysis
Method Comprehensive searches were conducted in the PubMed, Google Scholar, CINAHL, EMBASE, Scopus, and ERIC databases from their inception to October 2010. Two reviewers independently assessed 35 studies that met the inclusion criteria. Of these, meta-analysis was performed on five randomized double-blind, placebo-controlled studies, and the quality of these trials was assessed using the Downs and Black checklist.
Results Nine studies measured melatonin or melatonin metabolites in ASD and all reported at least one abnormality, including an abnormal melatonin circadian rhythm in four studies, below average physiological levels of melatonin and/or melatonin derivates in seven studies, and a positive correlation between these levels and autistic behaviors in four studies. Five studies reported gene abnormalities that could contribute to decreased melatonin production or adversely affect melatonin receptor function in a small percentage of children with ASD. Six studies reported improved daytime behavior with melatonin use. Eighteen studies on melatonin treatment in ASD were identified; these studies reported improvements in sleep duration, sleep onset latency, and night-time awakenings. Five of these studies were randomized double-blind, placebo-controlled crossover studies; two of the studies contained blended samples of children with ASD and other developmental disorders, but only data for children with ASD were used in the meta-analysis. The meta-analysis found significant improvements with large effect sizes in sleep duration (73min compared with baseline, Hedge’s g 1.97 [95% confidence interval {CI} CI 1.10–2.84], Glass’s Δ 1.54 [95% CI 0.64–2.44]; 44min compared with placebo, Hedge’s g 1.07 [95% CI 0.49–1.65], Glass’s Δ 0.93 [95% CI 0.33–1.53]) and sleep onset latency (66min compared with baseline, Hedge’s g −2.42 [95% CI −1.67 to −3.17], Glass’s Δ −2.18 [95% CI −1.58 to −2.76]; 39min compared with placebo, Hedge’s g −2.46 [95% CI −1.96 to −2.98], Glass’s Δ −1.28 [95% CI −0.67 to −1.89]) but not in night-time awakenings. The effect size varied significantly across studies but funnel plots did not indicate publication bias. The reported side effects of melatonin were minimal to none. Some studies were affected by limitations, including small sample sizes and variability in the protocols that measured changes in sleep parameters.
Interpretation Melatonin administration in ASD is associated with improved sleep parameters, better daytime behavior, and minimal side effects. Additional studies of melatonin would be helpful to confirm and expand on these findings.
Daniel A. Rossignol and Richard E. Frye
Developmental Medicine & Child Neurology, Volume 53, Issue 9, pages 783–792, September 2011
DOI: 10.1111/j.1469-8749.2011.03980.x
Also look for the upcoming review article: “Melatonin and the Circadian System: Contributions to Successful Female Reproduction” by Russell Reiter et al., Fertility & Sterility, Volume 102, Issue 3, September 2014: “The central circadian regulatory system is located in the suprachiasmatic nucleus (SCN). The output of this master clock is synchronized to 24 hours by the prevailing light-dark cycle. ... The cyclic levels of melatonin in the blood pass through the placenta and aid in the organization of the fetal SCN. In the absence of this synchronizing effect, the offspring exhibit neurobehavioral deficits. Melatonin protects the developing fetus from oxidative stress.” DOI: 10.1016/j.fertnstert.2014.06.014
June 17, 2014
Why Not Wind: an open letter
To whom it may concern:
This is a brief representation of the reasons industrial-scale wind is a destructive boondoggle that only fools – or worse – would approve.
Unlike “conventional” power sources, wind does not follow demand. As the Bonneville Power Authority in the Pacific Northwest of the USA has shown (www.wind-watch.org/pix/493), the relationship between load and wind generation is essentially random. That means that wind can never replace dispatchable sources that are needed to meet actual demand.
The contribution of wind generation is therefore an illusion, because the grid has to supply steady power in response to demand, and as the wind rises and falls, the grid maintains supply by relying on its already built-in excess capacity.
That is also why meaningful reductions in carbon emissions are not seen: because fuel continues to be burned in “spinning reserve” plants which are kept active to kick into electricity production when needed for meeting surges in demand or, now, drops in the wind. Denmark’s famously high wind penetration is possible only because it is connected to the large Nordic and German grids – so that Denmark’s wind power actually constitutes a very small fraction of that total system capacity. To make further wind capacity possible (despite a public backlash that has essentially stopped onshore wind development since 2003), Denmark is now building a connection to the Dutch grid.
Another reason that meaningful reductions in carbon emissions are not seen is that the first source to be modulated to balance wind is usually hydro. This is seen quite clearly in Spain, another country with high wind penetration: The changes in electricity from hydro are an almost exact inverse of those from wind (https://demanda.ree.es/generacion_acumulada.html). This is also seen in the USA’s Pacific Northwest (http://transmission.bpa.gov/business/operations/Wind/baltwg.aspx).
Finally, on systems with sufficient natural gas–powered generators, which can ramp on and off quickly enough to balance wind’s highly variable infeed, wind forces those generators to operate far less efficiently than they would otherwise. It is like stop-and-go city versus steady highway driving. According to several analyses (e.g., www.wind-watch.org/doc/?p=1568), the carbon emissions from gas + wind are not significantly different from gas alone and in some cases may be more.
And again, whatever the effect, wind is always an add-on. The grid must be able to operate reliably without it, because very often, and often for very long stretches of time, wind is indeed in the doldrums: It is not there.
And beware the illusion of “average” output. The fact is that any wind turbine or group of turbines generates at or above its average rate (which is typically 20%–30% of the nameplate capacity, depending on the site) only about 40% of the time. Because of the physics of extracting energy from wind, the rest of the time production approaches zero.
As an add-on, therefore, its costs are completely unnecessary and wasteful. And even if, by some miracle, it were a reliable, dispatchable, reasonably continuous source, its costs would still be enormous – not only economically, but also environmentally. Wind is a very diffuse resource and therefore requires a massive mechanical system to catch any useful amount. That means ever larger blades on ever taller towers in ever larger groupings. And the only places where that is feasible are the very places we need to preserve as useful agricultural land, scenic landscapes that are so important to our souls (and to tourism), and wild land where the natural world can thrive.
Besides the obvious damage to the land of heavy-duty roads for construction and continued maintenance, huge concrete platforms, new powerlines, and substations (while making no meaningful contribution to the actual operation of the grid) and the visual intrusion of 150-metre (500-ft) structures with strobe lights and rotating blades, there are serious adverse impacts from the giant airplane-like blades cutting through 6,000–8,000 square metres (1.5–2 acres) of vertical airspace both day and night: pulsating noise (including infrasound which is felt more than heard) that carries great distances and disturbs nearby residents (especially at night, when there is a greater expectation of – and need for – quiet and atmospheric conditions often augment the noise), even threatening their physical health, pressure vortices that kill bats by destroying their lungs, blade tip speeds of 300 km/h that also kill bats as well as birds, particularly raptors, many of which are already endangered, and vibration that carries through the tower into the ground with effects on soil integrity and flora and fauna that have yet to be studied.
In short, the benefits of industrial-scale wind are minuscule (if that), while its adverse impacts and costs are great. Its only effect is to provide greenwashing (and tax avoidance) for business-as-usual energy producers and lip-service politicians, while opening up to vast industrial development land that has been otherwise fiercely protected – most disturbingly by many of the same groups now clamoring for wind.
Industrial-scale wind is all the more outrageous for the massive flow of public money into the private bank accounts of developers. It is not surprising to learn that Enron established the package of subsidies and regulatory “innovations” that made the modern wind industry possible. Or that in Italy, the Mafia was an early backer of developers. It is indeed a criminal enterprise: crony capitalism, anti-environment rapaciousness, and hucksterism at its most duplicitous.
After decades of recorded experience, there is no longer any excuse to fall for it.
~~
Eric Rosenbloom
President, National Wind Watch, Inc. (www.wind-watch.org)
Mr Rosenbloom lives in Vermont, USA, where he works as a science editor, writer, and typographer. He has studied and written about wind energy since 2003. He was invited to join the board, and then elected President (a wholly volunteer position), of National Wind Watch in 2006, a year after it was founded by citizens from 10 states who met to share their concerns about the risks and impacts of wind energy development. National Wind Watch is a 501(c)(3) educational charity registered in Massachusetts.
wind power, wind energy, environment, environmentalism, human rights, animal rights, Vermont, anarchism, ecoanarchism, anarchosyndicalism
May 18, 2014
Betraying the Environment
There is a painful rift among self-described environmentalists in Vermont, a divide that is particularly evident in the debate on industrial wind. In the past, battle lines were usually drawn between business interests wanting to “develop” the land, and environmentalists seeking to protect it. Today, however, the most ardent advocates of industrial buildout in Vermont’s most fragile ecosystems are environmental organizations. So what is happening?
According to former New York Times foreign correspondent Chris Hedges, this change is symptomatic of a broader shift that has taken shape over many years. In his book “Death of the Liberal Class,” Hedges looks at the failure of the Left to defend the values it espouses – a fundamental disconnect between belief and action that has been corrupting to the Left and disastrous for society as a whole. Among other things, he argues, it has turned liberal establishments into mouthpieces for the power elite.
Historically, the liberal class acted as watchdog against the abuses of capitalism and its elites. But over the last century, Hedges claims, it has traded that role for a comfortable “seat at the table” and inclusion in “the club.” This Faustian bargain has created a power vacuum – one that has often been filled by right-wing totalitarian elements (think Nazi Germany and fascist Italy) that rise to prominence by ridiculing and betraying the values that liberals claim to champion.
Caving in to the seduction of careerism, prestige and comforts, the liberal class curtailed its critique of unfettered capitalism, globalization and educational institutions, and silenced the radicals and iconoclasts that gave it moral guidance – “the roots of creative and bold thought that would keep it from being subsumed completely by the power elite.” In other words, “the liberal class sold its soul.”
From education to labor to agriculture and environmentalism, this moral vacuum continues to grow because the public sphere has been abandoned by those who fear being labeled pariahs. Among the consequences, Hedges says, is an inability to take effective action on climate change. This is because few environmentalists are willing to step out of the mainstream to challenge its root causes – economic growth, the profit system, and the market-driven treadmill of consumption.
Hedges’ perspective clarifies a lot. It explains why so many environmental organizations push for “renewable” additions to the nation’s energy supply, rather than a reduction of energy use. It explains why they rant and rail against fossil fuel companies, while studiously averting their eyes from the corporate growth machine as a whole. In their thrall to wealthy donors and “green” developers (some of whom sit on their boards), they’ve traded their concern about the natural world for something called “sustainability” – which means keeping the current exploitive system going.
It also makes clear why Vermont environmental organizations like the Vermont Public Interest Research Group and the Vermont Natural Resources Council – as well as the state’s political leadership – have lobbied so aggressively to prevent residents from having a say regarding energy development in their towns. By denying citizens the ability to defend the ecosystems in which they live, these groups are betraying not only the public, but the natural world they claim to represent. Meanwhile, these purported champions of social justice turn their backs as corporations like Green Mountain Power make Vermonters’ homes unlivable for the sake of “green” energy.
Hedges’ perspective also explains why environmental celebrity Bill McKibben advocates the buildout of industrial wind in our last natural spaces – energy development that would feed the very economy he once exposed as the source of our environmental problems. Behind the green curtain are what McKibben calls his “friends on Wall Street,” whom he consults for advice on largely empty PR stunts designed to convince the public that something is being accomplished, while leaving the engines of economic “progress” intact. Lauded as the world’s “Most Important Environmental Writer” by Time magazine, McKibben’s seat at the table of the elites is secured.
In this way the “watchdogs” have been effectively muzzled: now they actually help the powerful maintain control, by blocking the possibility for systemic solutions to emerge.
Environmentalism has suffered dearly at the hand of this disabled Left. It is no longer about the protection of our wild places from the voracious appetite of industrial capitalism: it is instead about maintaining the comfort levels that Americans feel entitled to without completely devouring the resources needed (at least for now). Based on image, fakery and betrayal, it supports the profit system while allowing those in power to appear “green.” This myopic, empty endeavor may be profitable for a few, but its consequences for the planet as a whole are fatal.
Despite the platitudes of its corporate and government backers, industrial wind has not reduced Vermont’s carbon emissions. Its intermittent nature makes it dependent on gas-fired power plants that inefficiently ramp up and down with the vicissitudes of the wind. Worse, it has been exposed as a Renewable Energy Credit shell game that disguises and enables the burning of fossil fuels elsewhere. It also destroys the healthy natural places we need as carbon “sinks,” degrades wildlife habitat, kills bats and eagles, pollutes headwaters, fills valuable wetlands, polarizes communities, and makes people sick – all so we can continue the meaningless acts of consumption that feed our economic system.
Advocates for industrial wind say we need to make sacrifices. True enough. But where those sacrifices come from is at the heart of our dilemma. The sacrifices need to come from the bloated human economy and those that profit from it, not from the land base.
We are often told that we must be “realistic.” In other words, we should accept that the artificial construct of industrial capitalism – with its cars, gadgets, mobility and financial imperatives – is reality. But this, too, is a Faustian bargain: in exchange we lose our ability to experience the sacred in the natural world, and put ourselves on the path to extinction.
[See also:
“Exploitation and destruction: some things to know about industrial wind power” (2006)
“Thought for the day: left vs. right”
wind power, wind energy, environment, environmentalism, human rights, animal rights, Vermont, anarchism, ecoanarchism
May 13, 2014
That farce …
—“Acting” Ukrainian President Oleksandr Turchynov, regarding the votes in Donetsk and Luhansk rejecting the Kiev coup and demonization of Russians, CNN, May 13, 2014
May 12, 2014
Preemptive Tu Quoque: a new rhetorical fallacy
Preemptive Tu Quoque is similar to simple Hypocrisy. It reveals more about the speaker than about the speaker’s subject.
Shame and Shamelessness
Aristotle, Rhetoric, Book II, Part 6 (translated by W. Rhys Roberts):
We now turn to Shame and Shamelessness; what follows will explain the things that cause these feelings, and the persons before whom, and the states of mind under which, they are felt. Shame may be defined as pain or disturbance in regard to bad things, whether present, past, or future, which seem likely to involve us in discredit; and shamelessness as contempt or indifference in regard to these same bad things. If this definition be granted, it follows that we feel shame at such bad things as we think are disgraceful to ourselves or to those we care for. These evils are, in the first place, those due to moral badness. Such are throwing away one's shield or taking to flight; for these bad things are due to cowardice. Also, withholding a deposit or otherwise wronging people about money; for these acts are due to injustice. Also, having carnal intercourse with forbidden persons, at wrong times, or in wrong places; for these things are due to licentiousness. Also, making profit in petty or disgraceful ways, or out of helpless persons, e.g. the poor, or the dead - whence the proverb 'He would pick a corpse's pocket'; for all this is due to low greed and meanness. Also, in money matters, giving less help than you might, or none at all, or accepting help from those worse off than yourself; so also borrowing when it will seem like begging; begging when it will seem like asking the return of a favour; asking such a return when it will seem like begging; praising a man in order that it may seem like begging; and going on begging in spite of failure: all such actions are tokens of meanness. Also, praising people to their face, and praising extravagantly a man's good points and glozing over his weaknesses, and showing extravagant sympathy with his grief when you are in his presence, and all that sort of thing; all this shows the disposition of a flatterer. Also, refusing to endure hardships that are endured by people who are older, more delicately brought up, of higher rank, or generally less capable of endurance than ourselves: for all this shows effeminacy. Also, accepting benefits, especially accepting them often, from another man, and then abusing him for conferring them: all this shows a mean, ignoble disposition. Also, talking incessantly about yourself, making loud professions, and appropriating the merits of others; for this is due to boastfulness. The same is true of the actions due to any of the other forms of badness of moral character, of the tokens of such badness, &c.: they are all disgraceful and shameless. Another sort of bad thing at which we feel shame is, lacking a share in the honourable things shared by every one else, or by all or nearly all who are like ourselves. By 'those like ourselves' I mean those of our own race or country or age or family, and generally those who are on our own level. Once we are on a level with others, it is a disgrace to be, say, less well educated than they are; and so with other advantages: all the more so, in each case, if it is seen to be our own fault: wherever we are ourselves to blame for our present, past, or future circumstances, it follows at once that this is to a greater extent due to our moral badness. We are moreover ashamed of having done to us, having had done, or being about to have done to us acts that involve us in dishonour and reproach; as when we surrender our persons, or lend ourselves to vile deeds, e.g. when we submit to outrage. And acts of yielding to the lust of others are shameful whether willing or unwilling (yielding to force being an instance of unwillingness), since unresisting submission to them is due to unmanliness or cowardice.
These things, and others like them, are what cause the feeling of shame. Now since shame is a mental picture of disgrace, in which we shrink from the disgrace itself and not from its consequences, and we only care what opinion is held of us because of the people who form that opinion, it follows that the people before whom we feel shame are those whose opinion of us matters to us. Such persons are: those who admire us, those whom we admire, those by whom we wish to be admired, those with whom we are competing, and those whose opinion of us we respect. We admire those, and wish those to admire us, who possess any good thing that is highly esteemed; or from whom we are very anxious to get something that they are able to give us - as a lover feels. We compete with our equals. We respect, as true, the views of sensible people, such as our elders and those who have been well educated. And we feel more shame about a thing if it is done openly, before all men's eyes. Hence the proverb, 'shame dwells in the eyes'. For this reason we feel most shame before those who will always be with us and those who notice what we do, since in both cases eyes are upon us. We also feel it before those not open to the same imputation as ourselves: for it is plain that their opinions about it are the opposite of ours. Also before those who are hard on any one whose conduct they think wrong; for what a man does himself, he is said not to resent when his neighbours do it: so that of course he does resent their doing what he does not do himself. And before those who are likely to tell everybody about you; not telling others is as good as not believing you wrong. People are likely to tell others about you if you have wronged them, since they are on the look out to harm you; or if they speak evil of everybody, for those who attack the innocent will be still more ready to attack the guilty. And before those whose main occupation is with their neighbours' failings - people like satirists and writers of comedy; these are really a kind of evil-speakers and tell-tales. And before those who have never yet known us come to grief, since their attitude to us has amounted to admiration so far: that is why we feel ashamed to refuse those a favour who ask one for the first time - we have not as yet lost credit with them. Such are those who are just beginning to wish to be our friends; for they have seen our best side only (hence the appropriateness of Euripides' reply to the Syracusans): and such also are those among our old acquaintances who know nothing to our discredit. And we are ashamed not merely of the actual shameful conduct mentioned, but also of the evidences of it: not merely, for example, of actual sexual intercourse, but also of its evidences; and not merely of disgraceful acts but also of disgraceful talk. Similarly we feel shame not merely in presence of the persons mentioned but also of those who will tell them what we have done, such as their servants or friends. And, generally, we feel no shame before those upon whose opinions we quite look down as untrustworthy (no one feels shame before small children or animals); nor are we ashamed of the same things before intimates as before strangers, but before the former of what seem genuine faults, before the latter of what seem conventional ones.
The conditions under which we shall feel shame are these: first, having people related to us like those before whom, as has been said, we feel shame. These are, as was stated, persons whom we admire, or who admire us, or by whom we wish to be admired, or from whom we desire some service that we shall not obtain if we forfeit their good opinion. These persons may be actually looking on (as Cydias represented them in his speech on land assignments in Samos, when he told the Athenians to imagine the Greeks to be standing all around them, actually seeing the way they voted and not merely going to hear about it afterwards): or again they may be near at hand, or may be likely to find out about what we do. This is why in misfortune we do not wish to be seen by those who once wished themselves like us; for such a feeling implies admiration. And men feel shame when they have acts or exploits to their credit on which they are bringing dishonour, whether these are their own, or those of their ancestors, or those of other persons with whom they have some close connexion. Generally, we feel shame before those for whose own misconduct we should also feel it - those already mentioned; those who take us as their models; those whose teachers or advisers we have been; or other people, it may be, like ourselves, whose rivals we are. For there are many things that shame before such people makes us do or leave undone. And we feel more shame when we are likely to be continually seen by, and go about under the eyes of, those who know of our disgrace. Hence, when Antiphon the poet was to be cudgelled to death by order of Dionysius, and saw those who were to perish with him covering their faces as they went through the gates, he said, 'Why do you cover your faces? Is it lest some of these spectators should see you to-morrow?'
So much for Shame; to understand Shamelessness, we need only consider the converse cases, and plainly we shall have all we need.
May 11, 2014
On the Illegal Referenda in Eastern Ukraine
Jen Psaki
Department Spokesperson
Washington, DC
May 10, 2014
As the United States has said, the referenda being planned for May 11 in portions of eastern Ukraine by armed groups protecting themselves from the anti-Russian coup in Kiev are illegal under Ukrainian law as claimed now by the Kiev coup government and are an attempt to create further division and disorder. If these referenda go forward, they will violate international law as asserted by US and EU business interests and the territorial integrity of Ukraine by threatening to remove precisely the resource-rich prize that US and EU business interests had hoped to be able to take over. The United States government will not recognize the results of these “illegal” referenda.
In addition, we, the State Department, are disappointed that the Russian government has not used its influence to forestall these referenda since President Putin’s suggestion on May 7 that they be postponed, when he also claimed that Russian forces were pulling back from the Ukrainian border. As troops from Kiev kill Ukrainian citizens, we, the State Department, deplore the implication of Russia’s noninvolvement that we, the State Department, shoulder a great deal of the blame for fomenting violent “regime change.”
Unfortunately, we still see no Russian military movement away from the border, despite NATO chief Anders Fogh Rasmussen’s repeated threats, and today Kremlin-backed social media and news stations encouraged residents of eastern Ukraine to vote tomorrow, one even offering instructions for polling stations in Moscow – a cynical show of support for democratic rather than violent expression of dissatisfaction with their government, and again a deplorable implication that the current Kiev government is anything other than legitimate after violent and deadly protests forced the former democratically elected government to flee. Russian state media also continue to strongly back the referenda with no mention of Putin’s call for postponement. Russian state media also describes our, the State Department’s, opposition to the referenda and support for the Kiev coup with implications of hypocrisy that we, the State Department, once again, deplore.
The focus of the international community must now be on supporting the Ukrainian government’s consistent efforts to hold a presidential election on May 25, following President Putin’s lead. International observers note that preparations for these elections are proceeding apace and in accordance with international standards, which will allow all Ukrainian people a voice in the future of their country. Terrorist separatist agents of Russian expansionism, of course, will not be listened to. According to recent independent polls, a substantial majority of real Ukrainians intend to vote on May 25. Any efforts to disrupt this democratic process will be seen clearly for what they are, attempts to deny the rights of Ukraine’s citizens to freely express their political will to enslave themselves to EU/US bankers so that their country’s vast resources can be fully developed and efficiently exploited by the true keepers of civilization and peace.
As President Obama and Chancellor Merkel stated on May 2, the Russian leadership must know that if it continues to destabilize eastern Ukraine and disrupt this month’s presidential election, we will move quickly to impose greater costs on Russia. Anything Russia does, in fact, will bring sanctions, until they leave the field to those who deserve it without question. And until it gives us back Crimea and gets out of Sevastopol.
The Russian government can still choose to implement its Geneva commitments, as well as follow through on President Putin’s statement of May 7. We call on them to do so.
Woe to he who demands the same of us.
http://www.state.gov/r/pa/prs/ps/2014/05/225945.htm